Hyper-responsive Toll-like receptor 7 and 9 activation in NADPH oxidase-deficient B lymphoblasts
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چکیده
منابع مشابه
Interleukin-7 and Toll-Like Receptor 7 Induce Synergistic B Cell and T Cell Activation
OBJECTIVES To investigate the potential synergy of IL-7-driven T cell-dependent and TLR7-mediated B cell activation and to assess the additive effects of monocyte/macrophages in this respect. METHODS Isolated CD19 B cells and CD4 T cells from healthy donors were co-cultured with TLR7 agonist (TLR7A, Gardiquimod), IL-7, or their combination with or without CD14 monocytes/macrophages (T/B/mono;...
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متن کاملInteraction of NADPH oxidase 1 with Toll-like receptor 2 induces migration of smooth muscle cells.
AIMS NADPH oxidase (Nox) isozymes that generate intracellular reactive oxygen species (ROS) and Toll-like receptor 2 (TLR2), an inflammatory mediator, are both involved in the development of atherosclerotic lesions. To identify the molecular connection between TLR2 and Nox isozymes in vascular remodelling, we analysed generation of ROS and pro-inflammatory cytokines in aortic smooth muscle cell...
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ژورنال
عنوان ژورنال: Immunology
سال: 2015
ISSN: 0019-2805
DOI: 10.1111/imm.12530